There is a lot of posts on http://forums.iis.net related to network performance. Actually, there was two today!. The problems can be different, but the common thread seems to be network performance. Windows Server 2008 (and R2) enabled a new network feature
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Read the complete post at http://blogs.iis.net/steveschofield/archive/2010/08/31/troubleshooting-iis-7-network-performance-issues-and-tcp-chimney-offload-receive-side-scaling-and-network-direct-memory-access.aspx